Specificity, Function, and Development of NK Cells: NK Cells: The Effector Arm of Innate Immunity

NK Cells: The Effector Arm of Innate Immunity

Author: Klas Karre and Marco Colonna Series: Current Topics in Microbiology and Immmunology

Springer Book Archives

The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules.

Product Unavailable

PRODUCT INFORMATION

Summary

Springer Book Archives

Description

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.