Neurobiology of Post-Traumatic Stress Disorder

Post-Traumatic Stress Disorder (PTSD) is a common and severe psychiatric disorder precipitated by exposure to a psychologically distressing event. PTSD is associated with significant morbidity and mortality and is characterised by the presence of three distinct, but co-occurring, symptom clusters. Research evidence suggests that PTSD has a neurobiological basis. Current research on the neurobiology of PTSD include the utilisation of functional brain imaging; molecular genetic research; the incorporation of cross-system research including neuroendocrine, neurochemical, and neuroimmunological systems. This book examines the neurobiological basis of PTSD and the future research goals in regards to these findings.

Leo Sher, MD is a psychiatrist with a background in internal medicine. His areas of research and clinical expertise include neurobiology, diagnosis, and treatment of mood, anxiety, and personality disorders, alcoholism, and suicidal behavior. He is Associate Professor of Psychiatry at Icahn School of Medicine at Mount Sinai and Director of the Inpatient Psychiatry Service at the James J Peters VA Medical Center in New York. He has authored about 600 scientific publications, is a reviewer for numerous medical journals, the recipient of several awards and the first researcher in North America who introduced the use of the combined dexamethasone suppression/corticotropin-releasing hormone stimulation test for psychiatric purposes. Dr. Sher has experience as a forensic psychiatric expert and consultant.

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