Introduction to Cancer Biology

From basic principles to insights into pioneering research, this introductory textbook provides the fundamentals of cancer biology that will enable students of biology and medicine to enter the field with confidence. It opens with a discussion of global cancer patterns, how cancers arise, and the risk factors involved. A description of the normal signalling pathways within cells then explains how DNA mutations affect proteins and what this means for the development and behaviour of tumours. Later chapters discuss methods for tumour detection, biomarker identification and the impact of genome sequencing, before reviewing the development of anti-cancer drugs and exciting current advances in treatment. With 50% new material, including two new chapters on genetic analysis of cancer and cancer chemotherapy, improved pedagogy, examples of revolutionising technologies in drug design and delivery, and useful online resources, this textbook offers an accessible and engaging account of cancer biology for undergraduate and graduate students.

'A comprehensive, engagingly written, accurate overview of a topic that has continued to rapidly evolve in recent years. As our knowledge of cancer's molecular underpinnings advances, it is essential to remain up-to-date and this book delivers. Each chapter is full of concise explanations and wonderful illustrations that convey complex concepts in a straightforward way. I highly recommend this valuable resource to all students of biology and medicine.' Andrew Lam, M.D., University of Massachusetts Medical School
'The new edition of Introduction to Cancer Biology has been well worth waiting for. It develops logically from the previous edition and brings our current understanding of all aspects of the nature of cancer biology up to date. Central to the book are chapters dealing with DNA, oncogenes, tumour suppressor genes and signalling pathways. The chapters convey the historical development of these ideas into our current understanding. Thus, the book is suitable for students, undergraduates and postgraduates with an interest or need, to develop an overview of cancer research.' Tony Bradshaw, Oxford Brookes University
'This textbook has easy to understand figures and clearly laid out chapters. My favourite is the logical roadmap describing how one should teach using this textbook. I never saw that before. I think the students will appreciate the 'pause and recap' throughout the book; what a great way to check your knowledge one step at a time.' Luiza Nogaj, Mount Saint Mary's University Los Angeles
'A comprehensive look at cancer biology and treatment with chemical-level precision.' John Schmidt, Villanova University, Pennsylvania

Robin Hesketh is Emeritus Professor in the Department of Biochemistry, University of Cambridge. He is also a Fellow of Selwyn College. His major research area is anti-angiogenic strategies for cancer therapy. He has lectured in undergraduate and post-graduate courses on cell and molecular biology and cancer and published over 100 research papers and seven books, including the 1st edition of Introduction to Cancer Biology (2012) and Understanding Cancer (2022) for Cambridge University Press.

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